Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process.
Population
Rat liver perfusion model
Comparison
Perfusion with canine lipoproteins containing… vs Rat chylomicron remnants
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports Apo-E as key remnant clearance determinant in models; leaves open human translation.
Structured PICO
P
Population
Rat liver perfusion model
I
Intervention
Perfusion with canine lipoproteins containing only the E apoprotein (apo-E HDLc)
C
Comparator
Rat chylomicron remnants (in competition experiments)
O
Outcome
Hepatic uptake kinetics (Km and Vmax) and receptor binding affinitysurrogate
The E apoprotein is identified as the major determinant responsible for the high-affinity hepatic recognition and clearance of chylomicron remnants.
Cite This Study
Sherrill et al. (1980) studied this question.