March 15, 2007Journal of the American Society of Nephrology
Left Atrial Volume Monitoring and Cardiovascular Risk in Patients with End-Stage Renal Disease
Key result
A 1-ml/m(2.7) per year increase in left atrial volume was associated with a 12% increase in the relative risk for fatal and nonfatal cardiovascular events (P < 0.001).
Why the study?
Do changes in left atrial volume predict fatal and nonfatal cardiovascular events in dialysis patients?
Population
191 dialysis patients with end-stage renal disease (ESRD)
Design
Cohort
Follow-up
27 +/- 13 months
Authors
Discussion
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Implication
May support serial echocardiography for CV risk stratification in dialysis patients; leaves open whether LA volume changes warrant intervention.
Study Design
Type
Cohort (n=191)
Structured PICO
Do changes in left atrial volume predict fatal and nonfatal cardiovascular events in dialysis patients?
P
Population
191 dialysis patients who underwent two echocardiograms 17 +/- 2 months apart, followed for 27 +/- 13 months.
E
Exposure
Echocardiographic monitoring of changes in left atrial volume (LAV) indexed by height(2.7) over 17 +/- 2 months
O
Outcome
Fatal and nonfatal cardiovascular events during 27 +/- 13 months follow-uphard clinical
Main Result
Relative Risk: 1.12
p-value: p=< 0.001
Changes in left atrial volume over time independently predict incident cardiovascular events in dialysis patients, suggesting serial echocardiography is useful for risk stratification.
Cite This Study
Tripepi et al. (2007) conducted a cohort in End-Stage Renal Disease (n=191). Increase in left atrial volume (LAV) was evaluated on fatal and nonfatal CV events (RR 1.12, p=< 0.001). A 1-ml/m(2.7) per year increase in left atrial volume was associated with a 12% increase in the relative risk for fatal and nonfatal cardiovascular events (P < 0.001).