Key result
A novel 5' splice variant of human PDE7A (PDE7A2) was isolated from skeletal muscle, encoding a 50 kDa high-affinity cAMP-specific phosphodiesterase localized to particulate cellular fractions.
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PDE7A2 may regulate localized cAMP in muscle; leaves open its physiological role and therapeutic potential.
Han et al. (1997) studied this question. A novel 5' splice variant of human PDE7A (PDE7A2) was isolated from skeletal muscle, encoding a 50 kDa high-affinity cAMP-specific phosphodiesterase localized to particulate cellular fractions.
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