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December 18, 2000Biochemical JournalOpen Access

Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes

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Authors

YCYounghun ChoiChangwon National University DEDag EkholmNational Institutes of Health JKJudith KrallOslo University Hospital

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Implication

May inform vascular-selective PDE targeting; leaves open isoform-specific regulation in cardiovascular disease.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Choi et al. (2000) studied this question.

synapsesocial.com/papers/6a92b3e171c7499eda183a6d https://doi.org/10.1042/bj3530041

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Role of phosphodiesterase isoenzymes in regulating intracellular cyclic AMP in adenosine-stimulated smooth muscle cells1995 · 16 citations
2Development of Decompensated Dilated Cardiomyopathy Is Associated With Decreased Gene Expression and Activity of the Milrinone-Sensitive cAMP PhosphodiesterasePDE3A1997 · 67 citations
3Sarcoplasmic reticulum-associated cyclic adenosine 5'-monophosphate phosphodiesterase activity in normal and failing human hearts.1991 · 100 citations
4Ca2+ uptake by cardiac sarcoplasmic reticulum from patients with idiopathic dilated cardiomyopathy.1989 · 151 citations
5Functions of the N-terminal Region of Cyclic Nucleotide Phosphodiesterase 3 (PDE 3) Isoforms2000 · 66 citations