Why the study?
Does increased arteriovenous oxygen difference compensate for low cardiac output during mild exercise in patients with severe heart failure?
Does increased arteriovenous oxygen difference compensate for low cardiac output during mild exercise in patients with severe heart failure?
Patients with severe heart failure maintain oxygen consumption during mild exercise by increasing peripheral oxygen extraction (arteriovenous oxygen difference) to compensate for an inadequate increase in cardiac output.
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Supports extraction compensation for blunted CO in severe HF; hypothesis-generating, needs prospective validation before clinical use.
Tanehata et al. (1998) studied this question.
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