What question did this study set out to answer?

To investigate the cytotoxic T-cell response against a metastasizing lymphoma variant compared to a non-metastasizing parental tumor line.

Tumor metastases and cell‐mediated immunity in a model system in DBA/2 mice.: Iv. Antigenic differences between a metastasizing variant and the parental tumor line revealed by cytotoxic T lymphocytes

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Randomized trial investigates cytotoxic t lymphocyte response to metastatic and parental tumor lines in mice, suggesting key immune distinctions.

To investigate the cytotoxic T-cell response against a metastasizing lymphoma variant compared to a non-metastasizing parental tumor line.
Spleens from tumor-bearing DBA/2 mice were analyzed for cytotoxic activity against tumor cells.
In vitro restimulation was employed to assess secondary cytotoxic T-cell memory response.
Cytotoxic T-cell activity was measured using 51Cr release assays and sensitivity to anti-Thy 1.2 serum.
Cytotoxic T-memory cells were induced by as few as 10 cells of the metastasizing ESb tumor.
Significant anti-tumor cytotoxic activity was only detected after in vitro restimulation of T lymphocytes.
Cytotoxic T cells distinguished between the antigens of the parental tumor Eb and its metastasizing variant ESb.

Schirrmacher et al. (1979) studied this question.

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Randomized trial investigates cytotoxic t lymphocyte response to metastatic and parental tumor lines in mice, suggesting key immune distinctions.