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February 12, 2009Journal of VirologyOpen Access

Metagenomic Analyses of Viruses in Stool Samples from Children with Acute Flaccid Paralysis

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Why the study?

What is the viral diversity in stool samples from children with nonpolio acute flaccid paralysis?

Population

35 South Asian children with nonpolio acute flaccid paralysis (AFP) and 6 healthy contacts

Design

Cross-sectional

Authors

JVJoseph VictoriaBoehringer Ingelheim (United States)AKAmit KapoorManagement Development InstituteLLLinlin LiZhengzhou University

Discussion

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Implication

Pyrosequencing uncovers greater viral diversity including novel species in nonpolio AFP stools than Sanger; leaves open etiologic roles pending prospective studies.

Structured PICO

What is the viral diversity in stool samples from children with nonpolio acute flaccid paralysis?

P
Population
35 South Asian children with nonpolio acute flaccid paralysis (AFP) and 6 healthy contacts
I
Intervention
Metagenomic analysis of stool samples (sequence-independent reverse transcription, PCR amplification, Sanger sequencing, and pyrosequencing)
O
Outcome
Detection and identification of viral nucleic acidssurrogate

Metagenomic analysis of stool samples from children with acute flaccid paralysis identified numerous known and novel viruses, expanding the known viral diversity in this population.

Cite This Study

Victoria et al. (2009) studied this question.

synapsesocial.com/papers/6a2087c115df8032213e990dhttps://doi.org/10.1128/jvi.02301-08
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Infectious causes of acute flaccid paralysis2003 · 122 citations
  2. 2Detection of enterovirus viraemia in blood donors2001 · 23 citations
  3. 3RNA structure-based ribosome recruitment: Lessons from the Dicistroviridae intergenic region IRESes2008 · 29 citations
  4. 4Cardioviruses Are Genetically Diverse and Cause Common Enteric Infections in South Asian Children2009 · 134 citations
  5. 5Comparison of cell culture with RT‐PCR for enterovirus detection in stool specimens from patients with acute flaccid paralysis2007 · 21 citations