December 1, 1983Journal of Cerebral Blood Flow & Metabolism
Regional Differences in Vascular Autoregulation in the Rat Brain in Severe Insulin-Induced Hypoglycemia
Why the study?
Does mean arterial blood pressure level affect regional cerebral blood flow during severe insulin-induced hypoglycemia in rats?
Population
Artificially ventilated rats subjected to a 30-min insulin-induced hypoglycemic coma
Comparison
Maintenance of mean arterial blood pressure at… vs Control
Design
Preclinical
Follow-up
30 minutes
Authors
Discussion
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Implication
Moderate hypotension may exacerbate selective brain injury in severe hypoglycemia; leaves open whether regional autoregulatory failure translates to humans.
Structured PICO
Does mean arterial blood pressure level affect regional cerebral blood flow during severe insulin-induced hypoglycemia in rats?
P
Population
Artificially ventilated rats (70% N2O) subjected to a 30-min insulin-induced hypoglycemic coma (with cessation of EEG activity)
I
Intervention
Maintenance of mean arterial blood pressure at 140, 120, 100, and 80 mm Hg during 30 min of hypoglycemia
C
Comparator
Control (implied by comparison to 'control' values)
O
Outcome
Local cerebral blood flow (CBF) in 25 brain structures measured autoradiographically with a [14C]iodoantipyrine techniquesurrogate
During severe hypoglycemia, moderate arterial hypotension can cause additional circulatory insults that affect some brain structures more than others due to regional loss of vascular autoregulation.
Cite This Study
Siesjö et al. (1983) studied this question.