Key result
hERG overexpression significantly increased reentry frequency in neonatal rat ventricular myocyte monolayers compared to control (21.12 vs 9.21 Hz; P<0.001).
Why the study?
Does hERG overexpression increase functional reentry frequency and contribute to its stability in neonatal rat ventricular myocyte monolayers?
Does hERG overexpression increase functional reentry frequency and contribute to its stability in neonatal rat ventricular myocyte monolayers?
Absolute Event Rate: 21.12% vs 9.21%
p-value: p=<0.001
Overexpression of hERG in neonatal rat ventricular myocyte monolayers dramatically accelerates reentry frequency and stability due to APD and wavelength shortening along with transient hyperpolarization.
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Hypothesis-generating for hERG in reentry mechanisms; leaves open clinical translation pending in vivo and human studies.
Hou et al. (2010) studied Cardiac reentry and fibrillation (in vitro model) (n=59). hERG (I(Kr)) overexpression vs. GFP (control) or dominant negative mutant hERG G628S was evaluated on Reentry frequency (p=<0.001). hERG overexpression significantly increased reentry frequency in neonatal rat ventricular myocyte monolayers compared to control (21.12 vs 9.21 Hz; P<0.001).
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