Key result
Terminal repolarization in canine ventricular cells is dominated by IK1, while Ito is inactive during the plateau and neither IK1 nor IKr is frequency-dependent.
In canine ventricular cardiomyocytes, terminal repolarization is dominated by IK1, but the frequency dependence of action potential duration at normal and slow heart rates must be driven by currents other than Ito, IK1, or IKr.
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Refines canine repolarization models; leaves open ionic drivers of rate-dependent APD for human translation.
Bányász et al. (2007) studied this question. Action potential clamp was evaluated on Parametric description of K+ currents (Ito, IKr, IK1). Terminal repolarization in canine ventricular cells is dominated by IK1, while Ito is inactive during the plateau and neither IK1 nor IKr is frequency-dependent.
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