September 1, 1993Cardiovascular Research

Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Canine Purkinje fibres and isolated cat ventricular myocytes

Intervention

WAY-123,398 (a new class III antiarrhythmic agent)

Comparator

Dofetilide, E-4031, and dl-sotalol (for canine Purkinje fibres)

Outcome

Action potential duration (APD) and ionic currents (delayed rectifier IK, L-type Ca current ICa-L, inward rectifier IK1, and transient outward Ito)surrogate

WAY-123,398 is a specific class III antiarrhythmic agent that prolongs cardiac repolarization by blocking the delayed rectifier current (IK) without reverse use dependence.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

WAY-123,398 shows selective IK blockade in feline models; leaves open translation to human class III antiarrhythmic use.

Cite This Study

Spinelli et al. (1993) studied this question.

synapsesocial.com/papers/6a208889ee274fb2963e8960 https://doi.org/10.1093/cvr/27.9.1580

View Full Paper

Ask AI

Bookmark

Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes

Structured PICO

Discussion

Implication

Cite This Study

Cellular electrophysiology of WAY-123,398, a new class III antiarrhythmic agent: specificity of IK block and lack of reverse use dependence in cat ventricular myocytes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider