July 1, 1990Circulation

Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytes.

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Population

Isolated cat ventricular myocytes

Design

Preclinical

Authors

CFC H FollmerWest Los Angeles College TCThomas ColatskyUnited States Food and Drug Administration

Discussion

Member takes

Implication

Hypothesis-generating for flecainide mechanism in animal myocytes; leaves open human translation and clinical relevance.

Structured PICO

Population

Isolated cat ventricular myocytes

Intervention

Flecainide (10 microM) and E-4031 (1 microM)

Outcome

Block of the delayed rectifier potassium current (IK)surrogate

Flecainide and E-4031 both potently block the delayed rectifier potassium current (IK) in ventricular myocytes, which contributes to their antiarrhythmic properties.

Cite This Study

Follmer et al. (1990) studied this question.

synapsesocial.com/papers/6a20799014cb6ef00ff48d4b https://doi.org/10.1161/01.cir.82.1.289

View Full Paper

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Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider