Why the study?
Does E-4031 block the ATP-sensitive potassium channel in rabbit ventricular myocytes?
Population
Ventricular myocytes obtained by standard enzymatic dissociation techniques from New Zealand white rabbits
Design
Preclinical
Authors
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Suggests possible off-target IKATP effects in myocytes; leaves open in vivo relevance or impact on human electrophysiology.
Does E-4031 block the ATP-sensitive potassium channel in rabbit ventricular myocytes?
E-4031 blocks the ATP-sensitive potassium channel from within the cytoplasm, acting as an open channel blocker of intermediate to slow time course.
West et al. (1996) studied this question.
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