Key result
Children and adolescents with IDDM and poor glycemic control (HbA1c >10%) had significantly longer filtered QRS duration and lower root mean square voltage on SA-ECG compared to healthy controls (p<0.05).
Why the study?
Does signal-averaged electrocardiogram (SA-ECG) detect subclinical cardiac impairment in children and adolescents with insulin-dependent diabetes mellitus compared to healthy controls?
Population
34 children and adolescents, comprising 16 patients with insulin-dependent diabetes mellitus and 18…
Comparison
Signal-averaged electrocardiogram (SA-ECG) vs Age-matched healthy subjects
Design
Case-control
Authors
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SA-ECG abnormalities in poorly controlled pediatric IDDM suggest subclinical effects; hypothesis-generating and should not yet change practice.
Case-Control (n=34)
Does signal-averaged electrocardiogram (SA-ECG) detect subclinical cardiac impairment in children and adolescents with insulin-dependent diabetes mellitus compared to healthy controls?
p-value: p=< 0.05
SA-ECG may be a useful non-invasive tool to detect subclinical cardiac impairment, such as ventricular late potentials, in children and adolescents with poorly controlled type 1 diabetes.
Shiono et al. (2001) conducted a case-control in Insulin-dependent diabetes mellitus (n=34). Insulin-dependent diabetes mellitus vs. Age-matched healthy subjects was evaluated on Signal-averaged electrocardiogram parameters (f-QRS, RMS, LAS, LD) (p=< 0.05). Children and adolescents with IDDM and poor glycemic control (HbA1c >10%) had significantly longer filtered QRS duration and lower root mean square voltage on SA-ECG compared to healthy controls (p<0.05).
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