Why the study?
Do patients with diabetes mellitus exhibit prolonged QRS duration and more frequent late potentials on signal-averaging ECG compared to healthy subjects?
Do patients with diabetes mellitus exhibit prolonged QRS duration and more frequent late potentials on signal-averaging ECG compared to healthy subjects?
Patients with diabetes mellitus frequently exhibit intraventricular conduction disturbances on signal-averaging ECG, suggesting silent cardiac impairment likely due to diabetic microangiopathy.
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May indicate subclinical conduction delay in diabetes; leaves open prognostic value and need for prospective validation.
In order to detect silent impairment of the heart due to diabetes mellitus, the signal-averaging electrocardiograms (ECG) of 21 healthy subjects and 22 diabetic patients without ventricular tachycardia were compared. The QRS duration in the signal-averaging ECG was longer in diabetic patients than in the normal subjects (87.3 ms vs. 114.5 ms, p less than 0.01). Moreover, late potentials in the terminal portion of the QRS complex were observed in 7 diabetic patients (32%), but in only one normal subject (5%, p less than 0.01). These findings suggested that patients with diabetes mellitus frequently have intraventricular conduction disturbances, presumably due to diabetic microangiopathy.
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Yang et al. (1990) studied this question.
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