Key result
In patients with type 2 diabetes, a prolonged QTc interval significantly correlated with resting tachycardia (p=0.003), diabetic nephropathy (p=0.015), and non-proliferative diabetic retinopathy (p=0.0004).
Why the study?
Detailed 12 lead ECG analysis, an easily available investigation, may predict various microvascular and macrovascular complications in type 2 diabetes mellitus beyond coronary artery disease.
Does detailed ECG analysis predict microvascular and macrovascular complications in patients with type 2 diabetes mellitus?
Cross-Sectional (n=100)
No
Does detailed ECG analysis predict microvascular and macrovascular complications in patients with type 2 diabetes mellitus?
p-value: p=0.0004
Detailed ECG analysis, specifically identifying prolonged QTc and resting tachycardia, can serve as an early predictor for microvascular complications and cardiac autonomic neuropathy in patients with type 2 diabetes.
Background: Type 2 diabetes mellitus is a systemic disease with life-threatening complications and morbidity. The 12 lead ECG, an easily available investigation, when studied in detail can give a lot of information and predict various microvascular and macrovascular complications apart from coronary artery disease.Methods: A random cross sectional study involving 100 patients of type 2 diabetes mellitus, in the age group of 18-80 years were included in study after applying various inclusion and exclusion criteria. They were subjected to ECG, 2D echocardiography and laboratory tests. Data were collected and analysed.Results: Arrythmia was not detected in any patient. A resting tachycardia (HR >100) in 30 patients correlated with Prolonged QTc (>440 miliseconds) (p=0.04). QRS amplitude was reduced in 26 patients. Prolonged QTc also correlated with presence of diabetic complications, retinopathy of NPDR type and nephropathy (p=0.004). Hence about 30% of the study group did show signs of early diabetic cardiac autonomic neuropathy and cardiomyopathy.Conclusions: The statistically significant utility of electrocardiogram in predicting various complications of diabetes apart from coronary artery disease.
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Gokhale et al. (2020) conducted a cross-sectional in Type 2 diabetes mellitus (n=100). Prolonged QTc interval and resting tachycardia vs. Normal QTc interval and normal heart rate was evaluated on Correlation of prolonged QTc (>440 msec) with diabetic complications (nephropathy and retinopathy) (p=0.0004). In patients with type 2 diabetes, a prolonged QTc interval significantly correlated with resting tachycardia (p=0.003), diabetic nephropathy (p=0.015), and non-proliferative diabetic retinopathy (p=0.0004).
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