The 21% prevalence of late potentials in healthy middle-aged men is similar to values seen in myocardial infarction patients, suggesting the current definition of late potentials needs to be reconsidered.
High prevalence in healthy men questions late potential specificity for risk stratification; leaves open need for revised criteria in prospective studies.
Late potentials (LPS) have been shown to be predictive of ventricular tachycardia in coronary artery disease subjects, but the prevalence of LP in the general population is not as well-known. The study included 487 men without a history of cardiovascular disease (aged 50-59) living in Southwestern France. Standard-averaged high resolution electrocardiogram was performed using Butterworth filtering at 40-250 Hz. LPS were defined as two or more of the following criteria: QRS > 114 ms, duration of the low amplitude signals in the terminal portion of QRS > 38 ms, root mean square (RMS) voltage of the last 40 ms < 20 microV. The mean QRS duration was 97 +/- 12 ms (mean +/- SD), duration of the low amplitude signals in the terminal portion of QRS was 32 +/- 10 ms, and RMS voltage in the last 40 ms was 39 +/- 27 microV. Eight percent of subjects (95% confidence interval [CI]: 6%-11%) had a QRS duration > 114 ms; 22% (95% CI: 18%-26%) had a duration of low amplitude signals > 38 ms, and 25% (95% CI: 22%-29%) had RMS voltage in the last 40 ms < 20 microV. Finally, the prevalence of LP was 21% (95% CI: 18%-25%). In conclusion, according to commonly used criteria, the prevalence of LP in this healthy population of middle-aged men is 21%, close to the values found in the literature for myocardial infarction patients. Those findings indicate the need for reconsidering the definition of LPS.
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Marques‐Vidal et al. (2000) studied this question.
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