Why the study?
CTEPH causes significant morbidity and mortality, but long-term survival and health-related quality-of-life outcomes from contemporary multicenter studies are lacking.
Does pulmonary thromboendarterectomy improve survival and quality of life in patients with CTEPH?
Comparison
Operated vs operable but no surgery vs inoperable CTEPH
Design
Multicenter prospective cohort study
Follow-up
Up to 4 years
Key result
Inoperable status and operable but no surgery status in patients with CTEPH were associated with higher mortality rates relative to undergoing pulmonary thromboendarterectomy (HR 2.10; 95% CI 1.17-3.77 and HR 2.19; 95% CI 1.20-3.99, respectively).
Authors
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Supports pulmonary thromboendarterectomy consideration in operable CTEPH; leaves open randomized confirmation of survival benefit.
Cohort (n=750)
Yes
Does pulmonary thromboendarterectomy improve survival and quality of life in patients with CTEPH?
Hazard Ratio: 2.1 (95% CI 1.17–3.77)
In patients with CTEPH, undergoing pulmonary thromboendarterectomy is associated with significantly better long-term survival and quality of life compared to those who are inoperable or operable but do not undergo surgery.
Chin et al. (2023) conducted a cohort in Chronic thromboembolic pulmonary hypertension (CTEPH) (n=750). Inoperable or operable without surgery status vs. Pulmonary thromboendarterectomy (operated) was evaluated on Mortality (HR 2.10, 95% CI 1.17-3.77). Inoperable status and operable but no surgery status in patients with CTEPH were associated with higher mortality rates relative to undergoing pulmonary thromboendarterectomy (HR 2.10; 95% CI 1.17-3.77 and HR 2.19; 95% CI 1.20-3.99, respectively).