Key result
Three weeks after myocardial infarction in pigs, noninfarcted tissue adjacent to the infarct remodeled by expansion along the fiber and cross-fiber directions via myocyte elongation and cell slippage.
Population
Pig model of myocardial infarction
Design
Preclinical
Follow-up
3 weeks
Authors
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May inform border-zone remodeling mechanisms post-MI; leaves open translation to human ventricular remodeling.
This preclinical study demonstrates that post-MI remodeling in adjacent noninfarcted myocardium involves significant myocyte elongation and myofiber rearrangement.
Zimmerman et al. (2004) studied Myocardial infarction. Myocardial infarction was evaluated on Structural changes in noninfarcted tissue adjacent to the infarct. Three weeks after myocardial infarction in pigs, noninfarcted tissue adjacent to the infarct remodeled by expansion along the fiber and cross-fiber directions via myocyte elongation and cell slippage.
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