Population
Mouse model of acute myocardial infarction subjected to surgical coronary occlusion/reperfusion by left…
Comparison
Observation of left ventricular remodeling at 1… vs 1 week post-MI vs 4 weeks post-MI
Design
Preclinical
Follow-up
4 weeks
Key result
Surgical coronary occlusion/reperfusion in mice significantly decreased systolic regional wall thickening at 4 weeks compared to 1 week post-MI (-86% in border zone, P<0.05).
Authors
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Hypothesis-generating for scar extension in post-MI remodeling; leaves open translation to human HF progression.
Effect estimate: -86% in border zone, -77% in remote zone
p-value: p=<0.05
Fibrotic scar extension along mid-circumferential myofibers following the helical ventricular myocardial band model may account for progressive cardiac dysfunction during LV remodeling post-MI.
Kusakari et al. (2009) studied Myocardial infarction. Surgical coronary occlusion/reperfusion by LAD ligation vs. 1 week post-MI was evaluated on Systolic regional wall thickening (WT) in the border and remote zones (-86% in border zone, -77% in remote zone, p=<0.05). Surgical coronary occlusion/reperfusion in mice significantly decreased systolic regional wall thickening at 4 weeks compared to 1 week post-MI (-86% in border zone, P<0.05).