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February 1, 2000AJP Heart and Circulatory Physiology

Role of kinins in chronic heart failure and in the therapeutic effect of ACE inhibitors in kininogen-deficient rats

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Why the study?

Does ramipril improve cardiac remodeling and function after myocardial infarction in kininogen-deficient rats compared to normal rats?

Population

Brown Norway Katholiek rats and Brown Norway rats with myocardial infarction caused by coronary artery…

Comparison

Ramipril for 2 months, starting 2 months after… vs Vehicle

Design

Preclinical, randomly treated

Follow-up

2 months

Authors

YLYun-He LiuHenry Ford HospitalXYXiao-Ping YangShihezi UniversityDMDharmesh MehtaMaricopa Medical Center

Discussion

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Implication

ACEI post-MI benefits appear kinin-dependent in rats; leaves open translation to human HF therapy.

Structured PICO

Does ramipril improve cardiac remodeling and function after myocardial infarction in kininogen-deficient rats compared to normal rats?

P
Population
Brown Norway Katholiek (BNK) rats (kininogen-deficient) and Brown Norway (BN) rats (normal kininogen) with myocardial infarction caused by coronary artery ligation
I
Intervention
Ramipril (ACE inhibitor) for 2 months, starting 2 months after myocardial infarction
C
Comparator
Vehicle
O
Outcome
Left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), end-diastolic pressure (EDP), ejection fraction (EF), myocardial infarct size (IS), interstitial collagen fraction (ICF), cardiomyocyte cross-sectional area (MCA), and oxygen diffusion distance (ODD)surrogate

The cardioprotective effects of ACE inhibitors in heart failure after myocardial infarction are significantly dependent on endogenous kinins.

Cite This Study

Liu et al. (2000) studied this question.

synapsesocial.com/papers/6a208c263f9b8cb80cc63d80https://doi.org/10.1152/ajpheart.2000.278.2.h507
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of bradykinin in cardiac functional protection after global ischemia-reperfusion in rat heart1995 · 78 citations
  2. 2Role of Ca <sup>2+</sup> -Activated K <sup>+</sup> Channels in the Protective Effect of ACE Inhibition Against Ischemic Myocardial Injury1998 · 29 citations
  3. 3Angiotensin II in the Evolution of Experimental Heart Failure1996 · 70 citations
  4. 4Myocardial infarct size and ventricular function in rats.1979 · 1,283 citations
  5. 5Left ventricular diastolic pressure-volume relations in rats with healed myocardial infarction. Effects on systolic function.1981 · 363 citations