Why the study?
Does the lack of B2 kinin receptors diminish the cardioprotective effects of ACE inhibitors or AT1 receptor antagonists in mice with post-myocardial infarction heart failure?
Does the lack of B2 kinin receptors diminish the cardioprotective effects of ACE inhibitors or AT1 receptor antagonists in mice with post-myocardial infarction heart failure?
Kinins acting via the B2 receptor play an important role in mediating the cardioprotective effects of ACE inhibitors and AT1 receptor antagonists after myocardial infarction.
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B2 receptor mediation of ACEi benefits in post-MI mice is supported; hypothesis-generating and should not change practice.
Yang et al. (2001) studied this question.
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