Key result
Treatment of conditions such as hypercholesterolemia, hypertension, diabetes, and heart failure can improve arterial distensibility, reversing initial abnormalities.
Why the study?
Does treatment improve arterial distensibility in humans with cardiovascular risk factors or diseases?
Does treatment improve arterial distensibility in humans with cardiovascular risk factors or diseases?
Arterial distensibility is impaired in various cardiovascular and metabolic diseases, but can be improved with treatment, highlighting its role as a modifiable vascular parameter.
Answers are grounded in this paper and cite their sources.
Arterial distensibility may serve as a reversible marker in cardiovascular care; leaves open the need for randomized outcome trials.
Reduction of large artery distensibility has several adverse consequences for the cardiovascular system. This paper reviews the evidence obtained by measuring distensibility through quantification of changes in arterial diameter versus blood pressure changes at large elastic and middle size muscle artery sites. Evidence is available that arterial distensibility is reduced in conditions as varied as hypercholesterolemia, hypertension, diabetes and congestive heart failure. In some conditions (e.g. hypertension) the alterations are not uniformly distributed in arteries of different structure and size whereas in others (e.g. diabetes and heart failure) they are widespread. In diabetes evidence is available that distensibility changes occur early in the course of the disease. Evidence is also available that in all above conditions treatment can improve arterial distensibility thereby reversing the initial abnormality. This appears to be due to a variable combination of structural and functional factors. Technical ability to determine their precise role in distensibility changes in humans is limited, however.
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Giannattasio et al. (2002) conducted a review in Hypercholesterolemia, hypertension, diabetes, and congestive heart failure. Treatment was evaluated on Arterial distensibility. Treatment of conditions such as hypercholesterolemia, hypertension, diabetes, and heart failure can improve arterial distensibility, reversing initial abnormalities.
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