Elevated serum hypersensitive C-reactive protein levels were independently associated with an increased prevalence of non-alcoholic fatty liver disease in non-obese individuals, rising from 9.2% in the lowest quartile to 35.3% in the highest quartile.
Cross-Sectional (n=6,558)
No
Does elevated serum hs-CRP associate with the presence of NAFLD in non-obese people?
Elevated hs-CRP levels are independently associated with an increased risk of non-alcoholic fatty liver disease in non-obese individuals.
Absolute Event Rate: 35.3% vs 9.2%
p-value: p=<0.001
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) and obesity have become one of the most common chronic diseases, and the global prevalence is increasing year by year. Both are accompanied by hypersensitive C-reactive protein (hs-CRP). At present, there are many predictors of NAFLD. Exploring the relationship between hs-CRP and nonalcoholic fatty liver disease in non-obese people will be helpful for risk prediction and clinical screening in high-risk populations. OBJECTIVE: To explore the relationship between levels of serum hs-CRP and the presence of NAFLD in non-obese people. METHODS: A total of 6558 participants who underwent physical examination from March 2017 to November 2017. Multivariate logistic regression was utilized to analyze the risk factors associated with NAFLD. RESULTS: = 93.748, P < 0.001). In the nonalcoholic fatty liver group, various factors including hs-CRP, age, WC, BMI, systolic blood pressure and blood pressure diastolic blood pressure were significantly higher than those in the control group. Logistic regression analysis confirmed that hs-CRP was an independent risk factor for NAFLD, even after adjusting for relevant variables. CONCLUSIONS: The prevalence of NAFLD increases with the level of hs-CRP in both men and women who are non-obese. Hs-CRP levels are an important risk factor for nonalcoholic fatty liver disease in non-obese individuals.
Xia et al. (Tue,) conducted a cross-sectional in Non-alcoholic fatty liver disease (NAFLD) (n=6,558). High levels of serum hypersensitive C-reactive protein (hs-CRP) vs. Low levels of hs-CRP was evaluated on Presence of NAFLD (p=<0.001). Elevated serum hypersensitive C-reactive protein levels were independently associated with an increased prevalence of non-alcoholic fatty liver disease in non-obese individuals, rising from 9.2% in the lowest quartile to 35.3% in the highest quartile.