Key result
A higher predicted pro-inflammatory hs-CRP score was significantly associated with increased odds of NAFLD (highest vs lowest tertile OR 18.25; 95% CI 10.47-31.81; P<0.0001).
Why the study?
NAFLD is a major contributor to liver disease globally, but studies investigating the impact of diet and lifestyle factors on its development are limited.
Is a higher predicted pro-inflammatory hs-CRP score associated with increased odds of NAFLD in adults?
Cohort (n=1,076)
No
Is a higher predicted pro-inflammatory hs-CRP score associated with increased odds of NAFLD in adults?
Odds Ratio: 18.25 (95% CI 10.47–31.81)
p-value: p=<0.0001
A higher predicted pro-inflammatory hs-CRP score is strongly associated with increased odds of NAFLD, suggesting that anti-inflammatory dietary and lifestyle changes may help prevent NAFLD.
Predicted hs-CRP score may relate to NAFLD; hypothesis-generating and requires prospective validation before clinical use.
Background Non-alcoholic fatty liver disease (NAFLD) is a major contributor to liver diseases globally, yet there are limited studies investigating the impact of diet and lifestyle factors on its development. This study aimed to examine the association between the prevalence of NAFLD and predicted pro-inflammatory high-sensitivity C-reactive protein (hs-CRP) score. Methods We included 1,076 Korean adults who underwent a medical examination at the Seoul National University Hospital Gangnam Healthcare Center in Korea between May and December 2011 and updated in 2021. The predicted pro-inflammatory hs-CRP score was derived from pro-inflammatory demographic, lifestyle, dietary, and anthropometric factors, and NAFLD was diagnosed using liver ultrasound. Multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of NAFLD odds according to predicted pro-inflammatory hs-CRP score were estimated using logistic regression at a two-sided P < 0.05. Results Among the 1,076 participants, 320 had NAFLD. The multivariable-adjusted ORs and 95% CIs for NAFLD by tertiles of predicted pro-inflammatory hs-CRP score were 1.00, 3.30 (2.06, 5.30), 18.25 (10.47, 31.81; P < 0.0001) in men and women combined, 1.00, 1.77 (1.10, 2.84), and 3.26 (2.02, 5.28; P < 0.0001) among men only, and 1.00, 3.03 (1.39, 6.62), and 16.71 (7.05, 39.63; P < 0.0001) among women only. Conclusions Predicted pro-inflammatory hs-CRP score was associated with higher odds of NAFLD. Adopting dietary and lifestyle changes related to lower inflammation might be a valuable strategy for preventing NAFLD.
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Okekunle et al. (2022) conducted a cohort in Non-alcoholic fatty liver disease (NAFLD) (n=1,076). Predicted pro-inflammatory hs-CRP score vs. Lowest tertile of predicted pro-inflammatory hs-CRP score was evaluated on Non-alcoholic fatty liver disease (NAFLD) (OR 18.25, 95% CI 10.47-31.81, p=<0.0001). A higher predicted pro-inflammatory hs-CRP score was significantly associated with increased odds of NAFLD (highest vs lowest tertile OR 18.25; 95% CI 10.47-31.81; P<0.0001).
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