Structural characterization of cardiac protein phosphatase with a monoclonal antibody. Evidence that the Mr = 38,000 phosphatase is the catalytic subunit of the native enzyme(s).

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Population

Bovine and rat cardiac tissue extracts, as well as tissues from rabbits, mice, chickens, and human HT-29 cells

Design

Preclinical

Authors

Discussion

Does not inform clinical practice; extends molecular identification of cardiac phosphatase subunits in animal models.

Population

Bovine and rat cardiac tissue extracts, as well as tissues from rabbits, mice, chickens, and human HT-29 cells

Intervention

Monoclonal antibody directed against purified bovine cardiac Mr = 38,000 protein phosphatase

Outcome

Determination of whether the Mr = 38,000 species is the native catalytic subunit or a proteolytic productsurrogate

The Mr = 38,000 cardiac phosphatase is identified as a ubiquitous native catalytic subunit of higher molecular complexes.

Mumby et al. (1985) studied this question.

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