Why the study?
Does nitroglycerin alter left ventricular diastolic pressure-volume relations and relaxation in patients undergoing catheterization?
Does nitroglycerin alter left ventricular diastolic pressure-volume relations and relaxation in patients undergoing catheterization?
Nitroglycerin improves ventricular function partly by displacing the diastolic pressure-volume relation downward and leftward, likely due to relaxation of extracardiac constraints rather than changes in intrinsic ventricular relaxation.
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May explain nitroglycerin effects on LV filling during catheterization; supports hypothesis of extracardiac constraint relief in observational data.
Ludbrook et al. (1977) studied this question.
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