Key result
Vasoactive agents shift the left ventricular diastolic pressure-volume relation by altering pericardial pressure, allowing vasodilators to lower filling pressure without reducing cardiac output.
Design
Review
Authors
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Alerts clinicians to pericardial effects when interpreting vasodilator responses; extends diastolic physiology insights beyond myocardial distensibility.
The pericardial hypothesis explains that vasoactive agents alter the LV diastolic pressure-volume relationship by changing extraventricular constraint (pericardial pressure) rather than myocardial distensibility.
Smiseth et al. (1985) conducted a review in Heart failure / Angina pectoris. Vasoactive agents (vasodilators and vasoconstrictors) was evaluated. Vasoactive agents shift the left ventricular diastolic pressure-volume relation by altering pericardial pressure, allowing vasodilators to lower filling pressure without reducing cardiac output.
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