Key result
Release of -30 mmHg lower body negative pressure caused an acute decrease in left ventricular transmural filling pressure and a 3% drop in stroke volume, indicating pericardial constraint.
Why the study?
Does pericardial constraint modulate left ventricular filling when the heart is unloaded in healthy individuals?
Population
50 healthy individuals
Design
Other
Follow-up
15 heartbeats
Authors
Loading...
Pericardial constraint may limit LV filling during unloading in health; leaves open relevance to disease states.
Does pericardial constraint modulate left ventricular filling when the heart is unloaded in healthy individuals?
Pericardial constraint limits left ventricular filling even at low cardiac filling pressures in the unloaded heart, causing a transient drop in stroke volume during postural changes simulated by LBNP release.
Fujimoto et al. (2011) studied Healthy (n=50). Lower body negative pressure (LBNP) release was evaluated on Hemodynamic changes (LVTMP, SV, HR, BP) during LBNP release. Release of -30 mmHg lower body negative pressure caused an acute decrease in left ventricular transmural filling pressure and a 3% drop in stroke volume, indicating pericardial constraint.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: