Key result
In 20-week-old spontaneously hypertensive rats, QT duration was significantly prolonged compared to normotensive controls (100 vs 81 ms, p < 0.05) and correlated with systolic blood pressure.
Absolute Event Rate: 100% vs 81%
p-value: p=< 0.05
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Hypothesis-generating for QT changes in hypertension models; leaves open human translation and requires clinical studies.
Klimas et al. (2008) studied Hypertension and left ventricular hypertrophy. Spontaneous hypertension vs. Normotensive Wistar-Kyoto rats was evaluated on QT interval duration in vivo (p=< 0.05). In 20-week-old spontaneously hypertensive rats, QT duration was significantly prolonged compared to normotensive controls (100 vs 81 ms, p < 0.05) and correlated with systolic blood pressure.
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