Key result
Sevoflurane-based anesthesia did not reduce myocardial injury compared with total intravenous anesthesia, with increased TnT values in 44% vs 43% of patients (P=0.999).
Why the study?
Does sevoflurane-based anesthesia reduce myocardial injury (measured by increased troponin T) in patients undergoing elective abdominal aortic surgery compared to total intravenous anesthesia?
Population
193 patients scheduled for elective abdominal aortic surgery
Comparison
Sevoflurane-based anesthesia vs Total intravenous anesthesia
Design
RCT, Randomized, parallel-group, Open
Follow-up
First postoperative day
Authors
Loading...
Sevoflurane should not be selected over TIVA to reduce myocardial injury in aortic surgery; challenges assumptions of volatile anesthetic cardioprotection.
RCT (n=193)
Open-label
parallel-group
Does sevoflurane-based anesthesia reduce myocardial injury (measured by increased troponin T) in patients undergoing elective abdominal aortic surgery compared to total intravenous anesthesia?
Absolute Event Rate: 44% vs 43%
p-value: p=0.999
Sevoflurane-based anesthesia does not provide superior cardioprotection, as measured by troponin T release, compared to total intravenous anesthesia in patients undergoing elective abdominal aortic surgery.
Lindholm et al. (2013) conducted an RCT in elective abdominal aortic surgery (n=193). sevoflurane-based anesthesia vs. total intravenous anesthesia was evaluated on Increased TnT level (>13 ng/l) on the first postoperative day (p=0.999). Sevoflurane-based anesthesia did not reduce myocardial injury compared with total intravenous anesthesia, with increased TnT values in 44% vs 43% of patients (P=0.999).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: