Key result
Sevoflurane in patients with CAD undergoing peripheral vascular surgery resulted in a similar incidence of ischemia compared to propofol (25% vs 39%; P=0.126) but significantly lower cTnI release.
Why the study?
Does sevoflurane inhalation anesthesia reduce ischemic events and myocardial injury compared to propofol in patients with CAD undergoing peripheral vascular surgery?
Population
126 patients with coronary artery disease (CAD) scheduled for elective peripheral vascular surgery
Comparison
Sevoflurane inhalation anesthesia vs Total intravenous anesthesia with propofol
Design
RCT, Prospectively randomized
Follow-up
Hospital stay (up to 48 hours for continuous monitoring)
Authors
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Sevoflurane may reduce myocardial injury in CAD patients undergoing vascular surgery despite similar ischemia rates; extends RCT evidence for volatile anesthetic cardioprotection.
RCT (n=126)
prospectively randomized
Does sevoflurane inhalation anesthesia reduce ischemic events and myocardial injury compared to propofol in patients with CAD undergoing peripheral vascular surgery?
Absolute Event Rate: 25% vs 39%
p-value: p=0.126
Sevoflurane inhalation anesthesia provides superior cardioprotection compared to propofol by reducing postoperative myocardial ischemia and troponin release in CAD patients undergoing peripheral vascular surgery.
Amr et al. (2012) conducted an RCT in coronary artery disease (CAD) undergoing peripheral vascular surgery (n=126). Sevoflurane vs. Propofol was evaluated on Incidence of ischemia (p=0.126). Sevoflurane in patients with CAD undergoing peripheral vascular surgery resulted in a similar incidence of ischemia compared to propofol (25% vs 39%; P=0.126) but significantly lower cTnI release.
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