Key result
ACE inhibitor therapy was discontinued due to cough by 30.4% of newly prescribed patients in a Singapore primary healthcare cohort.
Why the study?
What is the incidence of discontinuation of ACE inhibitors due to cough in an Asian primary care population?
Cohort (n=424)
No
What is the incidence of discontinuation of ACE inhibitors due to cough in an Asian primary care population?
The incidence of ACE inhibitor discontinuation due to cough in a Singaporean primary care cohort is approximately 30%, which is significantly higher than reported in Caucasian populations, suggesting ARBs may be a reasonable first-line alternative in this demographic.
Answers are grounded in this paper and cite their sources.
High discontinuation in Asian primary care may favor initial ARBs; leaves open need for randomized ethnic comparisons.
A total of 424 patients were identified during the study period. Out of the 424 patients, 129 (30.4%) discontinued the use of ACE inhibitors due to cough. Overall, 90 (21.2%) patients who were initially started on ACE inhibitors were eventually switched to angiotensin receptor blockers (ARBs).
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Ng et al. (2014) conducted a cohort in Conditions requiring ACE inhibitors (e.g., diabetes mellitus, hypertension) (n=424). ACE inhibitors was evaluated on Incidence of discontinuation of ACE inhibitors due to cough. ACE inhibitor therapy was discontinued due to cough by 30.4% of newly prescribed patients in a Singapore primary healthcare cohort.
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