Sudden death risk in overt coronary heart disease: The Framingham Study
Why the study?
Does the development of overt coronary heart disease increase the risk of sudden death in a general population cohort?
Population
5127 subjects free of coronary heart disease (CHD) at baseline
Comparison
Development of overt coronary heart disease vs Subjects without an interim coronary heart…
Design
Cohort
Follow-up
30 years
Authors
Discussion
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Member takes
Implication
Manifest CHD events markedly elevate sudden death risk; extends prior cohorts but leaves causal pathways and preventive interventions open.
Structured PICO
Does the development of overt coronary heart disease increase the risk of sudden death in a general population cohort?
P
Population
5127 subjects free of coronary heart disease (CHD) at baseline
I
Intervention
Development of overt coronary heart disease (including myocardial infarction and angina pectoris)
C
Comparator
Subjects without an interim coronary heart disease event
O
Outcome
Sudden deathhard clinical
The development of overt coronary heart disease increases the risk of sudden death by 6.7-fold, with ischemic myocardial damage and cardiac failure being the chief predictors.
Cite This Study
Kannel et al. (1987) studied this question.