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September 17, 2026Journal of the American College of CardiologyOpen Access

Established CHD is linked to up to ~12-fold higher sudden death risk depending on age.

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Why the study?

Sudden coronary death is a major component of coronary mortality with variable risk factors and unclear specificity for sudden death, necessitating detailed population study analysis.

Population

Men and women with and without prior coronary heart disease in population studies

Comparison

Risk factors related to sudden death versus no sudden death

Design

Population-based observational studies

Key result

Overt established coronary heart disease increases the risk of sudden death 3-fold to 12-fold depending on age, while 50% of sudden deaths in men and 64% in women occur without prior disease.

Authors

WKWilliam B. KannelASArthur Schatzkin

Discussion

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Overview

Epidemiological review demonstrates distinct risk profiles for sudden cardiac death across population subsets, highlighting the need for targeted clinical prevention strategies.

Key Points

  • To review and synthesize epidemiological findings from population subsets to enhance risk assessment and prevention strategies for sudden cardiac death.
  • Evaluation of demographic and clinical subsets derived from prospective, population-based cohort studies
  • Analysis of risk markers, underlying cardiovascular etiologies, and incidence rates across defined demographic groups
  • Identification of differential risk factors across cohorts reveals that broad population screening often misses high-risk subgroups
  • Tailoring cardiovascular risk prediction to specific patient subsets improves the precision of early intervention and preventive protocols

PICO

P
Population
Sudden coronary death
E
Exposure / Comparator
Coronary risk factors and overt coronary heart disease
O
Primary Outcome
Sudden death

Cite This Study

Kannel et al. (1985) conducted a review in Sudden coronary death. Coronary risk factors and overt coronary heart disease was evaluated on Sudden death. Overt established coronary heart disease increases the risk of sudden death 3-fold to 12-fold depending on age, while 50% of sudden deaths in men and 64% in women occur without prior disease.

synapsesocial.com/papers/6aac043557aede4465be49c3https://doi.org/10.1016/s0735-1097(85)80545-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Instantaneous and Sudden Deaths1973 · 49 citations
  2. 2Survival after Resuscitation from Out-of-Hospital Ventricular Fibrillation1974 · 366 citations
  3. 3Diabetes and Glucose Tolerance as Risk Factors for Cardiovascular Disease: The Framingham Study1979 · 1,209 citations
  4. 4Postexercise peril. Plasma catecholamines and exercise1984 · 163 citations
  5. 5Epidemiological Approaches to Heart Disease: The Framingham Study1951 · 2,194 citations