Key result
Head-up tilt induced a significantly greater relative increase in QT variability unrelated to RR interval variability (ratio 2.19) compared to QT variability related to RR interval variability (ratio 1.45).
Why the study?
Does head-up tilt increase QT variability unrelated to heart rate variability in healthy volunteers?
Population
16 healthy volunteers (aged 29 ± 3 years) and simulated data
Comparison
Head-up tilt test analyzed with a novel… vs Early supine position
Design
Other
Authors
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Head-up tilt may preferentially increase intrinsic QT variability; this hypothesis-generating observation leaves open its arrhythmic risk implications.
Observational (n=16)
Does head-up tilt increase QT variability unrelated to heart rate variability in healthy volunteers?
p-value: p=≤0.05
The proposed time-varying nonparametric methodology accurately tracks changes in QT variability unrelated to heart rate variability, revealing that orthostatic challenge induces a greater relative increase in intrinsic ventricular repolarization variability than in heart rate-driven variability.
Orini et al. (2017) conducted an observational in Healthy (n=16). Head-up tilt vs. Supine position was evaluated on Relative increase in QTVuRRV (ratio of tilt vs early supine) (p=≤0.05). Head-up tilt induced a significantly greater relative increase in QT variability unrelated to RR interval variability (ratio 2.19) compared to QT variability related to RR interval variability (ratio 1.45).
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