Why the study?
Does hyperinsulinemia prolong the QTc interval in healthy volunteers?
Does hyperinsulinemia prolong the QTc interval in healthy volunteers?
Physiological hyperinsulinemia acutely prolongs ventricular repolarization (QTc interval), an effect mediated by insulin-induced hypokalemia and adrenergic activation.
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Should not change insulin management; leaves open arrhythmia risk in patients with comorbidities.
Gastaldelli et al. (2000) studied this question.
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