Key result
Congestive heart failure was associated with a significantly higher incidence of bronchial hyperreactivity compared to healthy controls (72% vs 4%, p < 0.05).
Why the study?
Is there a higher incidence of bronchial hyperreactivity in patients with congestive heart failure compared to healthy controls?
Case-Control (n=50)
Is there a higher incidence of bronchial hyperreactivity in patients with congestive heart failure compared to healthy controls?
Patients with congestive heart failure have a significantly higher incidence of bronchial hyperreactivity compared to healthy individuals.
Answers are grounded in this paper and cite their sources.
Supports further investigation of bronchial hyperreactivity in CHF; hypothesis-generating and should not alter management.
To study the incidence of bronchial hyperreactivity in patients of congestive heart failure. 50 subjects were divided into two groups. Group A was apparently healthy people taken as controls. Group B included patients of congestive heart failure. Both groups were then further subjected to spirometry followed by histamine bronchoconstriction test if FEV1/FVC > 85%. 1 subject out of 25 in group A as compared to 18 out of 25 in group B showed a fall in FEV1 of more than 20% on histamine challenge test. Hence the difference in bronchial hyperreactivity in both groups was statistically significant (p < 0.05). 72% of the patients of congestive heart failure demonstrated bronchial hyperreactivity whereas the incidence in normal controls was only 4%.
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Rana et al. (2018) conducted a case-control in Congestive heart failure (n=50). Congestive heart failure vs. Healthy controls was evaluated on Bronchial hyperreactivity (fall in FEV1 > 20% on histamine challenge test) (p=< 0.05). Congestive heart failure was associated with a significantly higher incidence of bronchial hyperreactivity compared to healthy controls (72% vs 4%, p < 0.05).
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