Key result
Higher systemic immune inflammation index is linked to aortic valve calcification in chronic renal failure.
Why the study?
Aortic valve calcification frequency increases with age and chronic renal failure, but the relationship between aortic valve calcification and systemic immune inflammation index in this elderly population required investigation.
Does the systemic immune inflammation index predict the presence of aortic valve calcification in elderly patients with chronic renal failure?
Observational (n=140)
No
Does the systemic immune inflammation index predict the presence of aortic valve calcification in elderly patients with chronic renal failure?
A higher systemic immune inflammation index is associated with aortic valve calcification in elderly patients with chronic renal failure, suggesting it could be an accessible biomarker for structural heart changes in this population.
May flag higher AVC risk in elderly renal failure patients; leaves open prognostic value and requires prospective validation.
Objectives: Aortic valve calcification (AVC) is a chronic, degenerative and progressive condition that results of endothelial injury, cholesterol deposition, myofibroblast differentiation and subsequent valve calcification, involving complex pathophysiological mechanisms such as the activation of inflammatory and immune system cells.The frequency of AVC increased in the presence of chronic renal failure (CRF) and with age.The study aimed to reveal the relationship between AVC and systemic immune inflammation index (SII) that includes peripheral neutrophil, lymphocyte and platelet counts in the elderly population with chronic renal failure. Materials and Methods:Patients over 65 years of age who applied to the cardiology outpatient clinic with chronic renal failure between March 2018 and October 2022 were included in the study.The patients were divided into two groups as group 1 (control group-undetected AVC on echocardiography) (70 patients) and group 2 (AVC detected on echocardiography) (70 patients).SII of all patients was defined as: SII = neutrophil count platelet count/lymphocyte count.Our study was a retrospective, observational study. Results:The mean SII value was statistically significantly higher in group 2 (754.2268.7)than group 1 (622.79297.2,p=0.007).
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Yurdam et al. (2023) conducted an observational in Chronic renal failure with or without aortic valve calcification (n=140). Systemic immune inflammation index (SII) vs. Lower systemic immune inflammation index was evaluated on Presence of aortic valve calcification on echocardiography (OR 1.002, 95% CI 1.000-1.005, p=0.034). Higher systemic immune inflammation index is independently associated with the presence of aortic valve calcification in older adults with chronic renal failure (OR 1.002, 95% CI 1.000-1.005, p=0.034).
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