What question did this study set out to answer?

To investigate the relationship between plaque inflammation and clinical stability in chronic stable angina patients.

October 1, 1996HeartOpen Access

Clinically stable angina pectoris is not necessarily associated with histologically stable atherosclerotic plaques.

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Why the study?

Is clinically stable angina associated with less plaque inflammation compared to unstable angina?

Population

58 patients who underwent directional coronary atherectomy, including chronic stable angina and unstable…

Comparison

Histological analysis of culprit lesions… vs Comparison between chronic stable angina and…

Design

Cohort

Authors

AWAllard C. van der WalVascular Medicine ABA E BeckerCross-Cutting Cardiology KKK. T. KochClinical Trials New Zealand

Discussion

Member takes

Implication

Stable angina associated with less plaque macrophage infiltration than unstable angina; supports inverse correlation with clinical stability but leaves open histologic risk stratification in stable patients.

Key Points

To investigate the relationship between plaque inflammation and clinical stability in chronic stable angina patients.
Retrospective study design involving 89 patients undergoing directional coronary atherectomy
Patients categorized into three groups based on angina stability
Main outcome measures included histological analysis of inflammatory cells in plaque tissues.
Chronic stable angina patients had larger areas of smooth muscle cells (51.2% vs. 42.1% and 29.5%) with P < 0.004 for group 1 vs 3.
Stable angina patients had significantly smaller macrophage-rich areas (21.8% vs. 31.5% and 46.4%) with P < 0.001 for group 1 vs 3.
T cell infiltration was lower in stable angina (17 vs. 25 and 41) with P < 0.001 for group 1 vs 3.

Structured PICO

Is clinically stable angina associated with less plaque inflammation compared to unstable angina?

Population

58 patients who underwent directional coronary atherectomy, including chronic stable angina (Canadian Cardiovascular Society classification 1-3, n=28) and unstable angina (Braunwald class II, n=18; Braunwald class III, n=12).

Intervention

Histological analysis of culprit lesions obtained via directional coronary atherectomy

Comparator

Comparison between chronic stable angina and unstable angina groups

Outcome

Tissue areas of culprit lesions occupied by inflammatory cells and smooth muscle cells related to clinically defined ischaemic syndromesurrogate

While inflammatory activity in plaque tissues inversely correlates with clinical stability, patients with clinically stable angina can still have histologically unstable plaques.

Cite This Study

Wal et al. (1996) studied this question.

synapsesocial.com/papers/6a209501f796ac642d951123 https://doi.org/10.1136/hrt.76.4.312

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Clinically stable angina pectoris is not necessarily associated with histologically stable atherosclerotic plaques.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Clinically stable angina pectoris is not necessarily associated with histologically stable atherosclerotic plaques.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider