Key result
Type II diabetes mellitus was associated with an insignificant difference in left ventricular systolic function compared to non-diabetics after early PCI for NSTEMI.
Why the study?
Cardiovascular diseases, particularly CAD, are leading causes of morbidity and mortality, prompting an assessment of how Type II DM impacts LV function measured by 2D speckle tracking echocardiography in middle-aged NSTEMI patients undergoing PCI.
Does Type II Diabetes Mellitus impact left ventricular function after early invasive management in middle-aged patients with NSTEMI?
Observational (n=60)
Yes
Does Type II Diabetes Mellitus impact left ventricular function after early invasive management in middle-aged patients with NSTEMI?
Early invasive intervention in middle-aged diabetic patients with NSTEMI appears to mitigate the adverse impact of diabetes on left ventricular systolic function.
Early PCI may equalize LV systolic function in diabetic vs non-diabetic NSTEMI; leaves open confirmation in randomized trials.
Background: Cardiovascular diseases are presently the leading causes of death in industrialized countries and expected to become so in emerging countries by 2020. Among these, coronary artery disease (CAD) is the most prevalent manifestation and is associated with high mortality and morbidity. Objective: The aim of this study was to assess the impact of Type II DM on the left ventricular function measured by 2D Speckle tracking Echocardiography in middle aged patients presenting with NSTEMI who will undergo PCI. Patients and methods: This study was carried on sixty middle aged patients (according to WHO, it should be 55 years of age) admitted with NSTEMI who undergoing (PCI) during their admission at Al-Hussein University Hospital, Mostafa Kamel Military Hospital and the International Cardiac Center (ICC) at Alexandria. They divided into two equal groups (Diabetic group and Non-diabetic control group). Results: The result showed that diabetes had a bigger effect on the initial systolic function but with early intervention.The difference in systolic function in both study groups was insignificant though it was a bit better in non-diabetics. Regarding to the site of significant LAD lesion, statistical difference was found in osteal LAD lesions (more in diabetics) and mid LAD lesions (more in non-diabetics). Conclusion: Early intervention in diabetic patients lessens the effect of CAD on the myocardium even if the disease tends to be stronger than non-diabetics early on. The 2D speckle tracking echocardiography is a promising, feasible, and non-invasive modality to evaluate myocardial deformation.
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Salama et al. (2019) conducted an observational in Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) (n=60). Type II Diabetes Mellitus vs. Non-diabetic was evaluated on Left ventricular systolic function measured by 2D Speckle tracking Echocardiography. Type II diabetes mellitus was associated with an insignificant difference in left ventricular systolic function compared to non-diabetics after early PCI for NSTEMI.
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