Why the study?
Does non-insulin-dependent diabetes mellitus affect infarct size and mortality in patients experiencing their first acute myocardial infarction?
Population
Study 1: 1059 patients with non-insulin-dependent diabetes mellitus and 1373 non-diabetic subjects aged…
Comparison
Non-insulin-dependent diabetes mellitus status vs Non-diabetic subjects
Design
Cohort
Follow-up
7 years (Study 1) and 28 days (Study 2 mortality)
Authors
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Diabetes may worsen post-MI prognosis via myocardial dysfunction independent of infarct size; hypothesis-generating for mechanisms.
Does non-insulin-dependent diabetes mellitus affect infarct size and mortality in patients experiencing their first acute myocardial infarction?
The poorer prognosis of acute myocardial infarction in diabetic patients is likely due to adverse effects of diabetes on myocardial function rather than a larger infarct size.
Lehto et al. (1994) studied this question.
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