Key result
Diabetes mellitus was associated with significantly higher long-term mortality (44% vs 23%, p=0.001) and in-hospital mortality (23% vs 5%, p<0.001) following acute myocardial infarction.
Why the study?
Does diabetes mellitus increase mortality in patients with acute myocardial infarction in the invasive era?
Cohort (n=334)
Does diabetes mellitus increase mortality in patients with acute myocardial infarction in the invasive era?
Absolute Event Rate: 44% vs 23%
p-value: p=0.001
Diabetes mellitus remains an independent risk factor for significantly increased short- and long-term mortality after acute myocardial infarction, even in the era of invasive therapy.
DM-associated mortality risk persists after AMI despite invasive care; extends observational data but leaves optimal interventions open.
OBJECTIVES: To investigate the outcome after acute myocardial infarction in diabetic patients compared with non-diabetic patients in a period with invasive treatment as the preferred treatment for acute myocardial infarction (MI). DESIGN: Patient records for all patients admitted with an acute MI in a two-year period from July 1, 2001 to June 30, 2003 were reviewed. RESULTS: A total of 334 patients entered the study: 48 with diabetes mellitus (DM) and 286 without diabetes. ST-elevation infarction occurred in 49% of non-diabetic patients and 36% of diabetic patients. In-hospital mortality was 23% among diabetic patients compared to 5% among non-diabetic patients (p < 0.001). Long-term mortality (median 2 years and 10 months) was 44% in diabetic-patients and 23% in non-diabetic patients (p = 0.001). Diabetic patients were older, more frequently had hypertension and three-vessel disease, but DM was found to be an independent risk factor for death after MI (p = 0.005). CONCLUSIONS: In an era of invasive therapy as the preferred therapy for acute MI, DM is still associated with considerably increased mortality after an acute MI.
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Hansen et al. (2006) conducted a cohort in acute myocardial infarction (n=334). Diabetes mellitus vs. No diabetes mellitus was evaluated on Long-term mortality (p=0.001). Diabetes mellitus was associated with significantly higher long-term mortality (44% vs 23%, p=0.001) and in-hospital mortality (23% vs 5%, p<0.001) following acute myocardial infarction.
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