The relationship between SV2A levels, neural activity, and cognitive function in healthy humans: A [11C]UCB-J PET and fMRI study

Figures

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  Fig. 1.. Mean activation during task switching in healthy subjects (n=23): Z. (Gaussianised T/F) statistical images representative of significant activation during the highSwitch>no-switch condition of the switching task. Images were thresholded using clusters determined by Z > 2.3 and a (corrected) cluster significance threshold ofp= 0.05. Axial slices shown in MNI152 are: -52 -42 -32 -22-12; -2 8 18 28; 38 48 56 66

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  Fig. 2.. Partial Least Squares Canonical Analysis (PLS-CA) showing a strong positive correlation between [11C]UCB-J DVRcs and task switching-related neural activity in the second canonical component (B) and no significant relationship in the first canonical component (A). Cov— covariance captured by each canonical correlation, significance thresholdp<0.05.

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  Fig. 3.. Scatter plot and Pearson’s correlation results showing a significant positive relationship between [11C]UCB-J DVRcs and high-switch>no-switch parameter estimates (PE) in the thalamus-putamen region of interest (ROI) (A), and lack of significant relationships between [11C]UCB-J DVRcs and high-switch>no-switch PE in the posterior frontal cortex ROI (B)

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  Fig. 4.. Two-component partial-least-squares regression results showing switch cost (s) are significantly predicted by [11C]UCB-J DVRcs values across six task-switching relevant regions of interest. Figure shows predicted switch cost plotted against observed switch cost, trend-line in red and 95% confidence interval shaded red.

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  Fig. 5.. Scatter plots showing results of Pearson’s correlations that show significant negative correlations between switch cost and [11C]UCB-J DVRcs in the (A) Insula, (B) dorsolateral prefrontal cortex (DLPFC), (C) parietal-precuneus, (D) posterior frontal cortex, (E) anterior cingulate cortex, and a trend towards a negative correlation in the (F) thalamus-putamen regions of interest.

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  Fig. 6.. N-back mean effect of task in the working memory contrast (n=25): Z (Gaussianised T/F) statistical images representative of significant activation during the 1&2back>0back condition of the N-back working memory task. Images were thresholded using clusters determined by Z > 2.3 and a (corrected) cluster significance threshold ofp= 0.05, axial slices shown in MNI152 are -52 -42 -32 -22-12; -2 8 18 28; 38 48 56 66

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  Fig. 7.. Partial Least Squares Canonical Analysis (PLS-CA) showing no significant correlation between [11C]UCB-J DVRcs and working memory-related neural activity (1&2back>0back PE) in both the first (A) and second (B) canonical components. Cov – covariance captured by each pair of components, significance thresholdp<0.05.

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  Fig. 8.. Two-component partial-least-squares regression results showing that N-back (s) is not significantly predicted by [11C]UCB-J DVR values across 6 working memory-relevant regions of interest. Figure shows predicted mean 1- and 2-back accuracy plotted against observed mean 1- and 2-back accuracy, trend-line in red, and 95% confidence interval shaded red.