Electronic cigarette exposure causes progressive vascular endothelial dysfunction via NADPH oxidase activation and eNOS uncoupling, occurring even with nicotine-free vaping.
Does electronic cigarette exposure cause vascular endothelial dysfunction?
Electronic cigarettes, even without nicotine, induce vascular endothelial dysfunction via oxidative stress and eNOS uncoupling, highlighting their potential cardiovascular risks.
Underlying mechanisms of e-cig-induced vascular endothelial dysfunction are delineated. e-cig exposure activates and increases expression of NADPH oxidase and disrupts activation and coupling of eNOS, leading to a vicious cycle of superoxide generation and peroxynitrite formation, with tetrahydrobiopterin depletion, causing loss of NO that triggers vascular endothelial dysfunction. This process is progressive, increasing with the duration of e-cig exposure, and is more severe in the presence of nicotine, but observed even with nicotine-free vaping.
El‐Mahdy et al. (Fri,) conducted a other in Vascular endothelial dysfunction. Electronic cigarette exposure was evaluated on Vascular endothelial dysfunction, NADPH oxidase activation, and eNOS uncoupling. Electronic cigarette exposure causes progressive vascular endothelial dysfunction via NADPH oxidase activation and eNOS uncoupling, occurring even with nicotine-free vaping.