Why the study?
No longitudinal data link intraglomerular hemodynamic dysfunction with end-stage kidney disease in people with type 2 diabetes.
Do intraglomerular hemodynamic parameters (RA-to-RE ratio and PGLO) predict incident end-stage kidney disease in people with type 2 diabetes?
Population
237 Pima Indian individuals with type 2 diabetes
Comparison
Trajectories of RA-to-RE ratio and PGLO
Design
Longitudinal cohort study
Follow-up
Median 17.5 years
Key result
Trajectories of increasing RA-to-RE ratio (HR 4.60; 95% CI 2.55-8.31) or elevated PGLO with rapid decline (HR 2.96; 95% CI 1.45-6.02) strongly predicted incident ESKD in type 2 diabetes.
Authors
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These trajectories may enhance ESKD risk stratification in T2D; leaves open whether they guide interventions or add to standard markers.
Cohort (n=237)
Do intraglomerular hemodynamic parameters (RA-to-RE ratio and PGLO) predict incident end-stage kidney disease in people with type 2 diabetes?
Hazard Ratio: 4.6 (95% CI 2.55–8.31)
Intraglomerular hemodynamic parameters, specifically increasing RA-to-RE ratio and elevated PGLO, strongly predict incident ESKD in patients with type 2 diabetes.
Saulnier et al. (2021) conducted a cohort in Type 2 diabetes (n=237). Increasing RA-to-RE ratio or elevated PGLO vs. Other trajectories was evaluated on Incident end-stage kidney disease (ESKD) (HR 4.60, 95% CI 2.55-8.31). Trajectories of increasing RA-to-RE ratio (HR 4.60; 95% CI 2.55-8.31) or elevated PGLO with rapid decline (HR 2.96; 95% CI 1.45-6.02) strongly predicted incident ESKD in type 2 diabetes.