Key result
Microinjection of muscimol, losartan, or MK-801 into the median preoptic nucleus attenuated the stress-induced increase in systemic vascular resistance and decrease in cardiac output in vascular responders.
Population
Sprague-Dawley rats
Design
Preclinical
Authors
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These rodent findings should not alter clinical practice; hypothesis-generating for median preoptic nucleus receptors in stress hemodynamics.
AT1 and NMDA receptors in the median preoptic nucleus play a critical role in mediating greater systemic vascular resistance responses to stress in vascular responder rats.
Schwartz et al. (2008) studied Hemodynamic response to stress. Microinjection of muscimol, losartan, or MK-801 into the MnPO was evaluated on Systemic vascular resistance (SVR) and cardiac output (CO) responses. Microinjection of muscimol, losartan, or MK-801 into the median preoptic nucleus attenuated the stress-induced increase in systemic vascular resistance and decrease in cardiac output in vascular responders.
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