Key result
Inactivation of the median preoptic nucleus (MnPO) by electrolytic lesion or lidocaine attenuated pressor responses to centrally administered ANG II and carbachol without changing resting arterial pressure.
Population
Preclinical model (species not specified in abstract)
Design
Preclinical
Authors
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Does not alter clinical hypertension management; leaves open MnPO as a central mediator pending human translation.
The median preoptic nucleus plays a crucial role in mediating pressor responses evoked by centrally administered angiotensin II and carbachol.
O’Neill et al. (1987) studied this question. Selective inactivation of the median preoptic nucleus (MnPO) via electrolytic lesion or lidocaine was evaluated on Pressor responsiveness to centrally administered ANG II and carbachol. Inactivation of the median preoptic nucleus (MnPO) by electrolytic lesion or lidocaine attenuated pressor responses to centrally administered ANG II and carbachol without changing resting arterial pressure.
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