Key result
Ibotenic acid lesion of the median preoptic nucleus markedly attenuated the hypertensive response to chronic angiotensin II and high salt diet, resulting in a mean arterial pressure of 122 mmHg compared to 143 mmHg in sham controls.
Why the study?
It was unclear whether median preoptic nucleus neurons or fibers of passage contribute to the hypertensive response to chronic angiotensin II in rats consuming a high salt diet.
Does ibotenic acid lesion of the median preoptic nucleus reduce chronic angiotensin II-salt induced hypertension in male Sprague Dawley rats?
Population
14 male Sprague Dawley rats
Comparison
Ibotenic acid lesion of the MnPO vs sham lesion
Design
Randomized preclinical animal study
Follow-up
14 days
Authors
Loading...
Should not inform clinical hypertension management; leaves open median preoptic nucleus neurons as a CNS target in AngII-salt models.
Does ibotenic acid lesion of the median preoptic nucleus reduce chronic angiotensin II-salt induced hypertension in male Sprague Dawley rats?
Absolute Event Rate: 122% vs 143%
p-value: p=<0.05
Neurons of the median preoptic nucleus are a critical component of the central nervous system signaling pathway mediating the hypertensive effects of chronic angiotensin II administration during increased dietary salt.
Collister et al. (2022) studied Angiotensin II-salt induced hypertension (n=14). Ibotenic acid lesion of the median preoptic nucleus (MnPOx) vs. Sham lesion was evaluated on Mean arterial pressure (MAP) at day 7 of AngII treatment (p=<0.05). Ibotenic acid lesion of the median preoptic nucleus markedly attenuated the hypertensive response to chronic angiotensin II and high salt diet, resulting in a mean arterial pressure of 122 mmHg compared to 143 mmHg in sham controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: