Key result
Differences in vascular reactivity to AngII may contribute to differences in haemodynamic response profiles to cocaine in individual rats, though they are not primary determinants.
Why the study?
Does baroreflex sensitivity and vascular reactivity covary with haemodynamic responsiveness to cocaine in conscious rats?
Population
Conscious rats (n=24 total; 16 vascular responders, 8 mixed responders)
Comparison
Cocaine and assessment of baroreflex sensitivity… vs Comparison between vascular responders and mixed…
Design
Preclinical
Authors
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Rat data on AngII reactivity offer no clinical guidance for cocaine responses; leaves open primary haemodynamic determinants for study.
Does baroreflex sensitivity and vascular reactivity covary with haemodynamic responsiveness to cocaine in conscious rats?
Differences in vascular reactivity to AngII may contribute to variable haemodynamic responses to cocaine in rats, though vascular responsivity and BRS do not appear to be primary determinants.
Traub et al. (2005) studied Haemodynamic responsiveness to cocaine (n=24). Cocaine vs. Vascular responders vs mixed responders was evaluated on Baroreflex sensitivity (BRS) and vascular reactivity. Differences in vascular reactivity to AngII may contribute to differences in haemodynamic response profiles to cocaine in individual rats, though they are not primary determinants.
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